Mind the gap! Connexins and pannexins in physiology, pharmacology and disease
نویسندگان
چکیده
منابع مشابه
Mind the gap! Connexins and pannexins in physiology, pharmacology and disease
Among other aspects it is the communication which makes the difference between a crowd of individuals and a society. Similarly, a key feature of an organism or of organs is the communication between their individual cells realized by mediators, hormones, and by direct intercellular communication via gap junction channels allowing the transmission of electrical signals and the exchange of small ...
متن کاملRoles of gap junctions, connexins, and pannexins in epilepsy
Enhanced gap junctional communication (GJC) between neurons is considered a major factor underlying the neuronal synchrony driving seizure activity. In addition, the hippocampal sharp wave ripple complexes, associated with learning and seizures, are diminished by GJC blocking agents. Although gap junctional blocking drugs inhibit experimental seizures, they all have other non-specific actions. ...
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Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function these proteins are frequently involved in pathological processes. The present paper reviews the role of connexins and pannexins in liver toxicity and disease. As they act both as sensors and effectors in these deleterious events connexins ...
متن کاملPannexins form gap junctions with electrophysiological and pharmacological properties distinct from connexins
Stable expression of pannexin 1 (Panx1) and pannexin 3 (Panx3) resulted in functional gap junctions (GJs) in HeLa cells, but not in Neuro-2a (N2a) or PC-12 cells. The glycosylation pattern of expressed Panx1 varied greatly among different cell lines. In contrast to connexin (Cx) containing GJs (Cx-GJs), junctional conductance (Gj) of pannexin GJs (Panx-GJs) is very less sensitive to junctional ...
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Under physiological conditions, microglia adopt a resting phenotype associated with the production of anti-inflammatory and neurotrophic factors. In response to a wide variety of insults, these cells shift to an activated phenotype that is necessary for the proper restoration of brain homeostasis. However, when the intensity of a threat is relatively high, microglial activation worsens the prog...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2013
ISSN: 1663-9812
DOI: 10.3389/fphar.2013.00144